Role of Gluthathione Pathway in Discovering Anticancer...

Cancer cell have different metabolism compare to normal cell and the modification in the metabolism turn normal cell to cancer cell (Akhdar et al 2012, p.137). In the human body, anticancer drug need to pass several metabolism to change it into other form before it will distributed to the target site and will be excreted through bile or urine. There are two different phases of enzymatic system that anticancer drug will become metabolite, namely phase I and phase II (Gonzalez 2005, p. 71). As the glutathione conjugation (phase II) plays main role in metabolism of anticancer compound, this point will be focused on. Glutathione are one of the major mechanisms controlling cellular oxidative balance (Pei et al 2013, p.2). There are three main function of glutathione (GSH) according to Pei et al (2013, p.2) : The role of glutathione can be explained by using example of human acute myelogenous leukemia (AML) cells. By targeting the glutathione pathway, this cancer cell will be stamped out. The primitive leukemia cells, which also known as leukemia stem cells (LSCs), are typically refractory to many forms of therapy.Research has been done to improve strategies for targeting of human AML cells by comparing the molecular mechanisms regulating oxidative state in primitive (CD34+) leukemic vs. normal specimens .By comparing this,,radox state is known as the most prevalent of the cellular properties known to differ in cancer vs.normal cell .From this,it shows that radoxShow MoreRelatedRole of Gluthathione Pathway in Discovering Anticancer Compound793 Words   |  3 Pages(Richard Manrow and Rebecca Chasan, 2013). In order to produce an effective and potent anticancer drug, there are several criteria we have to look into. For instance, the role of metabolism, cell environment and also protein homeostasis should be taken into account in discovering anticancer drug. To obtain the pharmacokinetic profile of an anticancer drug during the discovery process, metabolism plays a crucial role where the metabolic liability and the potential drug-drug interactions have to be determined